Givaudan Active Beauty unveils PrimalHyal™ NeuroYouth

Targeting ‘Neuro Skin Ageing’ to restore skin youth and sensory perception

Givaudan Active Beauty presents PrimalHyal™ NeuroYouth, an innovative complex based on low molecular weight hyaluronic acid and amino acids designed to address a recently identified skin ageing pathway defined by Givaudan Active Beauty as ‘Neuro Skin Ageing’.

By restoring nerve fibre function and neuronal communication, PrimalHyal™ NeuroYouth opens up a new frontier in skin health and well-ageing, where sensory perception becomes a new dimension of youthful-looking skin.

Beyond its protective barrier function, the skin is a living sensory network. With age, the skin’s nerve fibres become fewer, shorter and less functional, leading to decreased sensory perception, but also to impaired cellular communication and accelerated skin ageing.

To address this new longevity pathway, Givaudan Active Beauty has leveraged the skin’s natural affinity for very low molecular weight hyaluronic acid as a vector to optimise the delivery of selected amino acids within the skin. Inspired by microneedling delivery concepts described in cosmetic and pharmaceutical literatures, PrimalHyal™ NeuroYouth is a unique hyaluronic acid-base amino-acid complex designed to enhance skin bioavailability and the biological relevance of the amino acids.

Clinical studies conducted on more than 120 volunteers demonstrate that PrimalHyal™ NeuroYouth delivers visible and measurable anti-ageing benefits, including:

At the biological level, PrimalHyal™ NeuroYouth reverses the neuro-ageing pathway by enabling neuronal growth and density-related parameters, with a +28% increase in nerve fibre count and a +29% increase in nerve fibre length. It also enhances neuronal communication pathways through NGF-like activity and reactivates neuronal mitochondria energetic efficiency.

By supporting the skin’s neuro-sensory environment and helping to preserve skin homeostasis, PrimalHyal™ NeuroYouth contributes to stronger-looking, healthier and more comfortable skin, while enhancing the perceived capacity of the skin to sense and interact with its environment.

“Beyond aesthetics, PrimalHyal™ NeuroYouth redefines skin ageing from a skin health perspective. By addressing ‘Neuro Skin Ageing’, it offers new perspectives for the positioning of silver age, pre-juvenation and skin resilience concepts, where neurological health becomes a key pillar of youthful skin.”

Romain Reynaud, Research & Development Director at Givaudan Active Beauty

To learn more about Givaudan Active Beauty’s new ingredient and its inspirational concept, S3D® ReSense, Delight Body Lotion and S3D® ReSense, Youth-Awakening Serum, connect to uxbeauty.givaudan.com, Givaudan’s digital platform dedicated to cosmetic ingredients.