Tackling OxInflammation to Uphold Skin Health

Original content brought to you by our partner Givaudan Active Beauty.

Givaudan Active Beauty tackles OxInflammation to uphold skin health with Silybidiol™

Givaudan Active Beauty unveils Silybidiol™, the first globally compliant alternative to the iconic CBD (cannabidiol) molecule. Designed to combat the harmful effects of urban photo-pollution and promote skin health, Silybidiol™ is extracted from the fruit of the milk thistle with ‘green fractionation’. It offers a new, holistic approach to ageing, leveraging the emerging concept of OxInflammation, the vicious cycle connecting oxidative stress and inflammation.

In recent years, the perception of skincare and ageing has evolved towards a more positive and resilient approach known as ‘pre-aging’. This approach emphasizes the importance of self-care, focusing on prevention and overall wellbeing. It recognizes the link between positive emotional wellbeing and skin condition, promoting skin health and longevity. The exposome – the set of extrinsic aggressors to which our skin is exposed – is an important factor challenging skin health and longevity. It encompasses UV radiation and pollution, which disrupt the skin’s delicate OxInflammation balance – the interconnection of two key biological pathways. These factors can have a damaging cumulative effect on skin health and emotional balance.

Silybidiol™ binds to cannabinoid receptors in the skin and activates cellular crosstalk leading to the activation of skin defences and detoxification pathways to effectively maintain OxInflammation balance and promote wellbeing. Clinically tested versus placebo and CBD, on volunteers exposed to photo-pollution, Silybidiol™ offers:

  • a drastic improvement in skin homogeneity (2.7x better than CBD),
  • enhanced skin radiance (1.6x better than CBD),
  • an improvement in volunteers’ wellbeing (equivalent to CBD).
“We discovered that Silybidiol™ specifically activates CB2 cannabinoid receptors and delivers the same benefits as the hero CBD molecule. As such, not only does it reduce inflammation, which improves skin tone, but it also stimulates the production of beta-endorphins, feel-good peptides that contribute to overall wellness. This dual-action mechanism underlines Silybidiol™’s efficacy in promoting healthy, radiant skin while supporting emotional wellbeing.”

Romain Reynaud, Research & Development Director

giv silybidiol 800x533

Of 100% natural origin ISO 16128 and vegan suitable, Silybidiol™ complies with global standards.

It unlocks new perspectives to protect and reverse the consequences of the exposome for all consumers of beauty products.

To learn more about this new ingredient, connect to uxbeauty.givaudan.com, Givaudan Active Beauty’s digital platform dedicated to cosmetic ingredients or request your sample below.

Previous Post
Embrace the Blue: Join the Wave in Sustainable Suncare
Next Post
Beyond Sustainability: Premium Organic’s Regenerative Approach

More BUZZ

a detailed shot of the delicate petals of haberlea rhodopensis under morning dew
Givaudan, The Latest BUZZ

Epigenetic Claims—Without the Hype: Building Compliant Language From Methylome and Proteome Data

the beach sure is a beautiful place to be. shot of a group of happy young women having fun together at the beach.
Kalichem, The Latest BUZZ

Hybrid Sunscreens That Don’t Feel Heavy: Achieving High SPF With Lower Filter Load

beauty face. woman with natural makeup and healthy skin portrait
Givaudan, The Latest BUZZ

Radiance From Detox, Not Glitter: Engineering a “Natural Highlighter”

woman, deep breathing and meditation in nature and blue sky for mindfulness and spirituality. serene, peaceful and stress free for mental health wellbeing, religion and worship practise, generative ai
Seqens, The Latest BUZZ

The Mood–Skin Link in a Beaker: Formulating for Comfort Under Stress

two bottles of liquid foundation and two powder foundation compact cases on beige background
The Latest BUZZ, Uni-Powder

Hydration vs. Long Wear: How to Deliver “Glow” That Doesn’t Slip

portrait of a beautiful young woman with curly hair smiling in the sunshine, showcasing natural beauty and carefree spirit against a blurred urban background.
CLR, The Latest BUZZ

Skinmunity You Can Formulate: Counteracting UV-Induced Immunosuppression

white feather on a woman's bare shoulder
Seqens, The Latest BUZZ

Stop the Sting: Building Tinted Bases That Don’t Trigger Reactive Skin

smile beautiful brunette woman.
CLR, The Latest BUZZ

Postbiotic Pathways to Self-Defense: Training Skin to Protect Itself