Saffron’s Role in Restoring Comfort to Hypersensitive Skin

The Delicate Science Behind Sens’Flower™, a Solution for Reactive and Hypersensitive Skin

Sensitive skin is a common yet intricate challenge, where minor irritants can spark discomfort, redness, and inflammation. Traditional solutions often mask symptoms without addressing the underlying causes. Enter Sens’Flower™—a cutting-edge active ingredient from Seqens that transforms how we care for reactive and hypersensitive skin.

This innovative saffron flower extract marries centuries-old botanical wisdom with modern scientific expertise. Derived sustainably from Crocus sativus, it is rich in compounds that work at the molecular level to soothe irritation, strengthen the skin barrier, and reduce redness. But Sens’Flower™ does more than just alleviate symptoms—it restores comfort, resilience, and harmony to sensitive skin.

A Flower for the Sensitive Skin of the Modern World

dried saffron spice and saffron flower

Saffron, or Crocus sativus, has long held a place of prestige in human history. Known as “red gold,” this delicate flower’s uses span culinary, medicinal, and cosmetic traditions. But there’s more to saffron than its vibrant stigmas. Seqens has unlocked the untapped potential of the remaining flower petals, introducing Sens’Flower™, a saffron flower extract crafted to address the challenges of reactive and hypersensitive skin.

What Makes Sens’Flower™ Unique?

Derived from a sustainable and innovative process utilizing by-products collected from the remaining flower after the spice has been harvested, Sens’Flower™ contains glycosylated flavonoids such as quercetin and kaempferol; powerful compounds with soothing and anti-inflammatory properties. It is more than an ingredient—it’s a multi-faceted solution for sensitive skin.

How Sens’Flower™ Works: The Science of Soothing

sens'flower mechanism of action

1. Enhancing Skin Comfort
Sens’Flower™ reduces neuro-sensory discomfort by acting on TRPV1 receptors—key players in the sensation of tingling, burning, or irritation. By antagonizing these receptors, Sens’Flower™ ensures sensitive skin feels less reactive to environmental and sensory triggers.

2. Inhibiting Skin Inflammation
Inflammation can spiral out of control in hypersensitive skin, amplifying discomfort. Sens’Flower™ decreases pro-inflammatory responses by targeting markers such as NF-κB, a critical pathway in the body’s inflammatory response.

3. Boosting Skin Barrier Function
Sensitive skin often suffers from a compromised barrier, leading to moisture loss and vulnerability. Sens’Flower™ reinforces this barrier by enhancing profilaggrin synthesis, a precursor to filaggrin. Filaggrin plays a critical role in maintaining the skin’s natural moisturizing factors (NMFs) and hydrolipidic film integrity.

4. Reducing Redness
In clinical trials, Sens’Flower™ demonstrated its ability to reduce redness by 8% on average, with improvements of up to 16% after just 28 days of application. This effect helps restore a calm and balanced appearance to reactive skin.

Efficacy in Action

The efficacy of Sens’Flower™ has been rigorously validated through in vitro, in tubo, and clinical studies, demonstrating its effectiveness in soothing and strengthening sensitive skin. Among its notable results is its impact on skin redness.

Clinical Study: Reducing Redness

In a 28-day clinical study, 20 female volunteers with sensitive or reactive skin participated in a hemi-face application test. The study followed these parameters:

  • Participants: Women aged 45 ± 8 years with atopic tendencies.
  • Protocol: Twice-daily application of a placebo on one side of the face and a formulation with 4% Sens’Flower™ on the other.
  • Measurements: Red spots were assessed using SIAscope® biometric measurements at baseline (D0) and after 28 days (D28).
sens'flower clinical study redness

As a soothing active ingredient, Sens’Flower™ significantly reduces redness and brings comfort to sensitive skin at 4% Sens’flower™.

Skin redness is reduced by 8% on average and up to 16%.

Participants also reported noticeable improvements in comfort and overall skin condition, reaffirming Sens’Flower™ as a reliable solution for reactive and hypersensitive skin.

In Vitro: Skin Barrier Reinforcement & Anti-Inflammation
sens'flower skin barrier & nmf are reinforced

Sens’Flower™ strengthens the skin barrier as it stimulates the expression of profilaggrin (a precursor to filaggrin).

*Natural Moisturizing Factors

sens'flower anti inflammatory effect

Sens’Flower™ helps to reduce cutaneous discomfort by decreasing the proinflammatory response.

In Tubo: Skin Comfort and Skin Barrier Integrity
sens'flower sensation of cutaneous discomfort is decreased

Sens’flower™ helps to counteract skin sensitivity thanks to its antagonistic effect on the TRPV1 neurosensory receptor. This helps to avoid painful and uncomfortable sensations.

sens'flower the skin barrier and hydrolipidic film integrity are preserved

Sens’Flower™ helps to preserve the integrity of both the skin barrier and the hydrolipidic film by improving NMF formation and protecting the skin against lipoperoxidation.

Real-World Applications

Sens’Flower™ is ideal for a range of premium formulations, including:

  • Sensitive and reactive skin solutions
  • Delicate skincare products
  • Urban protection cosmetics
  • Organic and natural skincare lines

Its versatile properties also make it suitable for superfood-inspired formulations and clean beauty initiatives.

Why Choose Sens’Flower™?

With a commitment to sustainability and efficacy, Sens’Flower™ represents a marriage of science and nature. Developed through a robust CSR strategy and strong partnerships with independent farmers, this ingredient not only soothes the skin but also respects the planet. Seqens ensures that Sens’Flower™ meets rigorous compliance standards, including Cosmos certification and IECIC 2021 listing for China.

The Solution for Sensitive Skin

Reactive and hypersensitive skin can present a complex puzzle, but Sens’Flower™ offers a clear, scientifically-backed solution. Whether it’s enhancing comfort, reducing redness, or fortifying the skin’s barrier, this saffron flower extract addresses the needs of sensitive skin with precision and care.

Sens’Flower™ Brochure
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